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Understanding the Smart Insulin App Patch – Portal Diabetes & You

    Understanding the Smart Insulin App Patch - Portal Diabetes & You

    Researchers have developed a insulin delivery smart sticker that could one day revolutionize diabetes care by monitoring and controlling glucose levels in people with diabetes, providing the necessary dose of insulin.

    bioengineers of University of California at Los Angeles (University of California – Los Angeles) along with colleagues from UNC School of Medicine It is MIT developed a smart insulin patch, which is the size of a small coin.

    In the study, the researchers, led by Zhen Gu, PhD, professor of bioengineering at UCLA Samueli School of Engineeringdescribe the studies that were done in mice and pigs, and explain how the team is applying for FDA approval for human clinical trials.

    The team imagines that the smart microneedle patch could be adapted to different drugs to control other medical conditions as well.

    The study was published in Nature Biomedical Engineering .

    Revolutionizing diabetes care

    The smart diabetes patch monitors blood glucose levels and has preloaded doses of insulin in very small microneedles, less than a millimeter long, that rapidly inject medication when blood sugar levels reach a certain threshold .

    When blood glucose levels return to normal, insulin delivery from the patch also decreases. The researchers said the advantage is that it can help prevent high-dose insulin delivery, which can lead to hypoglycemia, seizures, coma or even death.

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    Hypoglycemia: signs, symptoms and treatment

    Gu, a former professor in the UNC/NCSU Joint Department of Biomedical Engineering, said: “Our main goal is to improve the health and quality of life of people with diabetes.”

    “This smart patch eliminates the need to constantly monitor blood glucose and then inject insulin when needed. It mimics the regulatory function of the pancreas, but in a user-friendly way.”

    What is insulin?

    Insulin is a hormone produced naturally in the pancreas that helps the body regulate glucose, which comes from eating food and provides the body with energy. Insulin is the molecular key that helps move glucose from the bloodstream into cells for energy and storage.

    Type 1 diabetes occurs when a person’s body does not produce insulin naturally. Type 2 diabetes occurs when the body does not efficiently use the insulin it produces. In both cases, a regular dose of insulin is prescribed to control the disease, which affects more than 465 million people worldwide, according to the IDF – International Diabetes Federation.

    Who needs insulin to live?

    Treatment of the disease hasn’t changed much in decades in most parts of the world. Patients with diabetes collect a small blood sample from the tip of their finger, using a device that measures glucose levels, called glucometers.

    Learn to choose a glucose meter

    They self-administer the required dose of insulin. Insulin can be injected with a needle and syringe or a pen-like device, or given through an insulin pump, which is a portable instrument about the size of a cell phone connected to the body through a tube with a needle in the extreme. The smart insulin patch would detect the need for insulin and deliver it.


    “It has always been a dream to achieve insulin delivery in a smart and convenient way,” said study co-author John Buse, MD, PhD, director of the UNC Diabetes Center and the North Carolina Institute for Translational and Clinical Sciences (NC TraCS) at the University of North Carolina at Chapel School of Medicine. Hill. “This smart insulin patch, if shown to be safe and effective in human trials, would revolutionize the patient experience in treating diabetes.”

    How does the diabetes patch work?

    The adhesive is simple to make and should work for 24 hours before it needs to be replaced. The microneedles used in the patch are made from a glucose-sensitive polymer that is encapsulated with insulin. Once applied to the skin, the microneedles penetrate below the skin and can detect blood glucose levels. If glucose levels rise, the polymer is activated to release insulin.

    Each microneedle is smaller than a normal needle used to draw blood and doesn’t penetrate as deeply into the skin, so the patch is less painful than a prick. Each microneedle penetrates approximately half a millimeter below the skin, which is enough to deliver insulin to the subcutaneous region of the body.

    In experiments, a coin-sized patch successfully controlled glucose levels in pigs with type I diabetes for about 20 hours (pigs weighed about 25 kilograms on average).

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    Co-author Robert Langer, ScD, a professor at the David H. Koch Institute at MIT, said: “I’m glad the team was able to bring this smart insulin patch one step closer to reality and we look forward to seeing it move forward one day to help people with diabetes.”

    The technology has been accepted into the ‘Emerging Technology Program’ of the FDA-Food and Drug Administration , which provides assistance to companies during the regulatory process. The researchers are applying for FDA approval for human clinical trials.

    Controlling blood glucose levels is key to avoiding complications

    Much is said about the complications caused by diabetes, such as:

    • Sight loss
    • kidney diseases
    • amputations
    • etc.

    Little is said about how diabetes affects the sexual health of people with this disease. To clarify these facts, Monica LenziI wrote the Digital Book “SEX and DIABETES – Everything you need to know.

    To find out, click the button below.

    SEX and DIABETES – Everything you need to know

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    Font: Health Europe

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