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Why weight matters in calculating diabetes risk – Portal Diabetes & You

    Diabetes: 7 Combinaciones de Jugos Naturales Nutritivos - Portal Diabetes y Tú

    The risk of developing diabetes continues to grow. The higher your blood sugar level, the greater the chance that you will later develop diabetes.

    If your fasting blood glucose is between 100 mg/dL and 126 mg/dL, you have what is known as prediabetes (Fasting blood sugar level above 126 mg/dL is defined as the diabetes). Like people with diabetes, prediabetics tend to be overweight, have high blood pressure and abnormal lipid levels, and are at increased risk of developing diabetes. cardiovascular disease.

    Fat is more than just a storage place for extra nutrients. Fat, or adipose tissue, also functions as a gland that produces hormones that affect appetite and insulin action. Until now, scientists have discovered that fat cells produce the hormones leptin, resistin, and adiponectin. Leptin is normally released after a meal and reduces appetite. Resistin and adiponectin affect the cells’ response to insulin (too much resistin can cause insulin resistance and too little adiponectin can do the same). It is becoming increasingly clear that excess body fat disrupts the balance and normal function of these hormones, contributing to insulin resistance and setting the stage for diabetes.

    LThe location of the fat is also important

    The risk of weight gain is especially high when excess weight is distributed around the abdomen, often called an “apple” shape, as opposed to fat around the hips, called a pear shape. Carrying excess weight around your waist also puts you at risk for a condition known as metabolic syndrome (see What is metabolic syndrome, below).

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    Fat can accumulate under the skin (known as subcutaneous fat) or around abdominal organs or viscera (known as visceral fat). A large belly suggests the presence of this harmful visceral fat, which produces hormones called cytokines that contribute to insulin resistance. For example, animals that are insulin resistant and obese have high levels of a cytokine called TNF-alpha. Some research suggests that this hormone may also play a role in people with insulin resistance.

    Other research suggests that visceral fat can affect levels of glucocorticoids, steroid hormones, which also contribute to obesity and insulin resistance. Additionally, fatty acids (from the breakdown products of fats) can play a direct role in insulin resistance when they are distributed into muscle, making the muscle more resistant to the action of insulin. Although research is still needed, it is becoming increasingly clear that fat, especially abdominal fat, negatively affects insulin action and contributes to the development of diabetes.

    What is metabolic syndrome?

    Metabolic syndrome is a term used to describe a constellation of risk factors for heart disease and stroke. Diabetes (or prediabetes), high cholesterol, high blood pressure, and obesity (especially abdominal obesity) are part of the syndrome, which is diagnosed if you have three or more of the following attributes:

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    A large waist size (more than 100 cm for men and 90 cm for women)

    Blood pressure of 130/85 millimeters of mercury (mm Hg) or higher

    Some experts believe that insulin resistance could be an underlying problem in metabolic syndrome. Also, if you have diabetes, your risk of developing retinopathy (eye disease), nephropathy (kidney disease), and neuropathy (nerve disease) increases dramatically, along with your risk of vascular diseases that affect the heart, brain and extremities.

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